Changelog

Feature updates and improvements to AlphaGenome Lookup.

v2.1.0

March 2026

New In-Silico Mutagenesis (ISM)

  • Dedicated ISM tab to scan genomic regions for variants that affect expression or splicing
  • Gene region options: Promoter (TSS ±500bp), 5'UTR, 3'UTR, or custom coordinates up to 200bp
  • Expression and splice scoring modes
  • Tissue-specific ISM scoring with searchable tissue selector
  • SeqLogo visualization showing positional mutational sensitivity
  • Top 10 upregulating and downregulating variants ranked in side-by-side tables

Improved UI Redesign

  • Two-tab layout: Variant Lookup and In-Silico Mutagenesis
  • Compact left-aligned design with info panels describing each tool
  • Searchable tissue dropdowns with type-to-filter on both tabs
  • Full-width expression score card for consistency with other sections

v2.0

March 2026

New Unified Analysis Report

  • Single-page report replaces the previous multi-tab layout
  • All results displayed in one view for easier interpretation

New Multi-Tissue Support

  • Analyze any tissue — no longer limited to skeletal and cardiac muscle
  • Multi-select tissue dropdown with 285+ available biosamples
  • Leave tissue selection empty to analyze across all tissues

New Configurable Analyses

  • Choose which analyses to run via checkboxes: Expression Scores, RNA Expression Tracks, Splice Scores, Splice Sites, Splice Junctions
  • Only selected analyses are computed, reducing wait times

Improved Expression Scoring

  • Expression scores now display all tissue samples for the target gene
  • Per-biosample breakdown with score range and direction

Improved Splicing Visualization

  • Adjustable zoom from 500bp (max detail) to 16kb (full view)
  • Zoom control located within the splicing section for easy access

Improved User Experience

  • Loading spinner on the Analyze button with progress bar
  • Clinical significance table and summary narrative
  • Splice site and junction interpretation cards

New Docker Support

  • Run locally with a single docker compose command
  • No Python environment setup required

v1.0

February 2026

New Initial Release

  • Variant lookup with splicing analysis (SPLICE_SITES)
  • Tissue expression analysis with RNA-Seq scoring
  • Skeletal and cardiac muscle dashboard with comparison
  • Sashimi plot visualization for splice junctions
  • Comprehensive splicing visualization (donor, acceptor, junctions, tissue usage)